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KMID : 0384320070280040271
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Korean Journal of Family Medicine
2007 Volume.28 No. 4 p.271 ~ p.277
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Influence of Metabolic Syndrome on Brachial-Ankle Pulse Wave Velocity
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Han Ah-Reum
Kim Jung-Ha
Lee Duk-Chul
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Abstract
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Background: Metabolic syndrome (MetS) is characterized by a core set of disorders, including abdominal besity,
dyslipidemia, glucose intolerance and hypertension. Many studies have shown that MetS is associated with increased risk of developing cardiovascular diseases and related mortality. However, the relationship of MetS with early stage of ardiovascular diseases, which is even more important from a prevention prespective, has not been examined extensively. Brachial-ankle pulse wave velocity (baPWV) is known to predict future cardiovascular events. Thus, we examined the elationship of MetS, defined using the NCEP-ATP III criteria, with baPWV. Methods: We examined a total of 400 participants who did not have a past history of either coronary heart disease or peripheral vascular disease. All subjects
underwent physical examination, blood chemistry, and baPWV.
Results: Compared with subjects without MetS, subjects with MetS had increased age, body mass index (BMI),
and ALT. Mean value of baPWV (adjusted for age, BMI, and blood pressure) was significantly higher in subjects with MetS (P=0.002). The baPWV was positively correlated with age, BMI, systolic and diastolic blood pressure in subjects with etS. In group without MetS, the baPWV was associated with age, waist circumference, blood pressure, total cholesterol, LDL cholesterol, triglyceride, fasting blood sugar, AST, ALT, homocysteine, CRP, and ferritin. The mean values of baPWV with 0, 1, 2, 3, 4, 5 components of MetS were 1,362.3±182.2 cm/s, 1,531.3±267.0 cm/s, 1,694.1±315.8 cm/s, 1,777.0±334.0 cm/s, 2,087.7±192.3 cm/s, respectively.
Conclusion: In this study, the MetS was associated with the risk for increased baPWV. (J Korean Acad Fam Med
2007;28:271-277)
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KEYWORD
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metabolic syndrome, brachial-ankle pulse wave velocity, cardiovascular disease
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